The world, post-apocalypse, in Stake Land is much like you've seen in other movies, although those probably had zombies instead of vampires. And actually, the vampires are much like zombies in this film, insofar that the way they are portrayed is as simple monsters with no human side at all. No explanation is given for the appearance of the vampires in the first place but that doesn't matter. The film is more centered on the characters and the journey they take with the vampires in the background, mostly because they are only a threat during the night. The new world that Mister and Martin travel around in is just desolate and dreary enough, giving the movie a nice atmosphere all the way through.
If we gotta talk vamps, I say that they look good in Stake Land. They do look a bit like the Buffy vamps from season 7, though. Just saying. The special effects are pretty much awesome looking all around. From the vampires themselves, to the staking deaths, to burned up bodies strewn around the street, this is not some shitty independent movie with ketchup for blood. The one really horrible thing they show is right at the beginning, in the flashback scene of the death of Martin's family. The vampire is slurping down on Martin's infant brother or sister and then casually drops the body when its done. That's just not right.
Stake Land is another one of those movies that doesn't get mentioned all that much, and it really should. Maybe you've seen movies similar to it before, but that shouldn't detract from the fact that Stake Land is impressively shot and acted. I'd definitely watch it again.